Skip to main content

Feedback regulation in biosynthesis of BCAA

 


Answer: 3. Leu will decrease and both Val and Ile will increase.

Explanation:
  • The problem states that IPMS activity is regulated exclusively by Leu, and the diagram shows that Leu is a product of the IPMS pathway. The RNAi knockdown of IPMS would lead to a decrease in the production of Leu.
  • The diagram also shows that both Leu and Val synergistically regulate the activity of AHAS. With a decrease in Leu, the inhibitory effect on AHAS is reduced, leading to an increase in AHAS activity.
  • An increase in AHAS activity leads to an increase in the production of 2-Oxoisovalerate, which is a precursor for both Val and the IPMS pathway.
  • Therefore, the concentration of Val will increase.
  • The problem states that Ile regulates TD activity, while Val can relax this feedback regulation. With an increase in Val, the feedback regulation on TD by Ile is relaxed, leading to an increase in TD activity and consequently an increase in the production of Ile. 
  • Therefore, the correct option is that Leu will decrease and both Val and Ile will increase.

Comments

Post a Comment

Popular posts from this blog

Given below are protein domains and their binding specificities.

        1. Given below are protein domains and their binding specificities.   which  one of the following options represents all correct matches between column X and Column Y ? A-iii, B-i, C-ii, D-ii A-i, B-ii, C-iii, D-i A-iii, B-iii, C-i, D-ii A- i, B-iii, C-ii, D-i Answer  : 4. A-i, B-iii, C-ii, D-i Domains are distinct functional or structural units within a protein. Each domain usually has a specific role or facilitates an interaction, contributing to the protein's overall function. Domains can be present in various biological contexts, and similar domains may be found in proteins that perform different functions.  SH2 domains were first identified in proteins encoded by the genomes of tumor-causing (oncogenic) viruses. These domains are composed of approximately 100 amino acids and feature a conserved binding pocket that accommodates a phosphorylated tyrosine residue. The human genome encodes over 110 SH2 domains, which play a crucial role...
Post a Comment
Read more

Population density and how determining population size?

Population density: Population density measures the number of individuals living in a specific area. It is usually expressed as: When the individuals are not mobile.         Population Density = Total Population/land Area (sq km or sq mile)      2. When individuals are very mobile and frequently   move from one area to another, we can determine the number of population sizes by applying the mark-recapture technique.   Mark-recapture technique: The mark-recapture technique was first developed by C.G.J. Petersen in 1896 and later refined by F.W. Lincoln in 1930. It is commonly known as the Lincoln-Petersen index when used for closed populations.     Total population size (N) = Total individuals captured, marked (M1), and released in the first sample (S1) x Size of the second recaptured sample (S2)/ Number of marked individuals recaptured in the second sample (M2) N= S1 x S2 / M2 Question:   In an experiment to determine the nu...
Post a Comment
Read more

Differences Between RPM and RCF in Centrifugation

    Differences Between RPM and RCF in Centrifugation In centrifuge operation, it is crucial to differentiate between two distinct units of measurement: Relative Centrifugal Force (RCF) and Revolutions Per Minute (RPM). These units are fundamentally different and confusing them—though not uncommon—can compromise the integrity of an experiment. This discussion will explore RCF and RPM in greater detail and examine their relationship. **Revolutions Per Minute (RPM) Revolutions Per Minute (RPM) refers to the measurement of the rotational speed of a centrifuge rotor, indicating the number of complete rotations it performs in one minute. This metric quantifies the rotor's spinning velocity. Each centrifuge has a specific speed range that varies by model. For instance, a low-speed centrifuge may operate at a minimum of 300 RPM, while a high-speed centrifuge can reach speeds of up to 15,000 RPM. Additionally, ultracentrifuges, the most powerful type, can exceed 150,000 RPM. **Relativ...
Post a Comment
Read more